Nuclear Pore Structure: Warming up the Core
نویسندگان
چکیده
منابع مشابه
Nuclear Pore Structure: Warming up the Core
Structural determination of the nuclear pore complex has been limited by the complexity and size of this cellular megalith. By taking advantage of exceptionally stable nucleoporins from the thermophilic fungus Chaetomium thermophilum, Amlacher et al. (2011) provide new insight into a core element of the nuclear pore scaffold.
متن کاملLighting up the nuclear pore complex.
It is generally accepted that transport through the nuclear pore complex (NPC) involves an abundance of phenylalanine-glycine rich protein domains (FG-domains) that serve as docking sites for soluble nuclear transport receptors (NTRs) and their cargo complexes. But the precise mechanism of translocation through the NPC allowing for high speed and selectivity is still vividly debated. To ultimat...
متن کاملThe structure of the nuclear pore complex.
In eukaryotic cells, the spatial segregation of replication and transcription in the nucleus and translation in the cytoplasm imposes the requirement of transporting thousands of macromolecules between these two compartments. Nuclear pore complexes (NPCs) are the sole gateways that facilitate this macromolecular exchange across the nuclear envelope with the help of soluble transport receptors. ...
متن کاملCaspases target only two architectural components within the core structure of the nuclear pore complex.
Caspases were recently implicated in the functional impairment of the nuclear pore complex during apoptosis, affecting its dual activity as nucleocytoplasmic transport channel and permeability barrier. Concurrently, electron microscopic data indicated that nuclear pore morphology is not overtly altered in apoptotic cells, raising the question of how caspases may deactivate nuclear pore function...
متن کاملCaspases Target Only Two Architectural Components within the Core Structure of the Nuclear Pore
Received for publication,October 31 , 2005, and in revised form, November 14,2005 Published, JBC Papers in Press, November 14, 2005, 0011 0.1 074/jbc.M5117172oo Monika Patre*, Anja Tabbert*, Daniela Hermann*, Henning Walczak§, Hans-Richard Rackwitz~, Volker C. Cordes ll**, and Elisa Ferrando-May*l From the *Molecular Toxicology Group, Faculty of Biology, University of Konstanz, 0-78457 Konstanz...
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ژورنال
عنوان ژورنال: Cell
سال: 2011
ISSN: 0092-8674
DOI: 10.1016/j.cell.2011.06.045